Tetrahedron

Towards the total synthesis of Calyculin C: preparation of the C 13–C 25 spirocyclic core

D Habrant, AJW Stewart, AMP Koskinen

Index: Habrant, Damien; Stewart, Alan J.W.; Koskinen, Ari M.P. Tetrahedron, 2009 , vol. 65, # 38 p. 7927 - 7934

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Citation Number: 15

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A stereoselective synthesis of the C 13 –C 25 of Calyculin C is described. Key steps involve the coupling of a terminal acetylene with a thiol ester and subsequent spirocyclisation using a double intramolecular hetero-Michael addition. ... Structure of Calyculin C. Structure of Calyculin C.

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