Tetrahedron letters

Cyclopropane PNA: observable triplex melting in a PNA constrained with a 3-membered ring

JK Pokorski, MC Myers, DH Appella

Index: Pokorski, Jonathan K.; Myers, Michael C.; Appella, Daniel H. Tetrahedron Letters, 2005 , vol. 46, # 6 p. 915 - 917

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Citation Number: 19

Abstract

The first peptide nucleic acid (PNA) with a cyclopropane in the backbone has been synthesized, and the effects of the ring on DNA/RNA binding properties of the PNA have been examined. Well-defined triplex to duplex melting transitions of PNA2 DNA complexes is clearly observed by variable temperature UV absorbance with the cyclopropane- constrained PNA.