Construction of targeting-clickable and tumor-cleavable polyurethane nanomicelles for multifunctional intracellular drug delivery

N Song, M Ding, Z Pan, J Li, L Zhou, H Tan…

Index: Song, Nijia; Ding, Mingming; Pan, Zhicheng; Li, Jiehua; Zhou, Lijuan; Tan, Hong; Fu, Qiang Biomacromolecules, 2013 , vol. 14, # 12 p. 4407 - 4419

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Citation Number: 41

Abstract

New strategies for the construction of versatile nanovehicles to overcome the multiple challenges of targeted delivery are urgently needed for cancer therapy. To address these needs, we developed a novel targeting-clickable and tumor-cleavable polyurethane nanomicelle for multifunctional delivery of antitumor drugs. The polyurethane was synthesized from biodegradable poly (ε-caprolactone)(PCL) and l-lysine ethyl ester ...