Synthesis and biological evaluation of orally active hypolipidemic agents

…, F Khan, J Mookkan, P Shetty, G Singh

Index: Bandgar, Babasaheb P.; Sarangdhar, Rajendra J.; Khan, Fruthous; Mookkan, Jeyamurugan; Shetty, Pranesha; Singh, Gajendra Journal of Medicinal Chemistry, 2011 , vol. 54, # 16 p. 5915 - 5926

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Citation Number: 10

Abstract

A series of novel fenofibric acid ester prodrugs 1c–1h were synthesized and evaluated with the aim of obtaining potent hypolipidemic agents. Prodrugs 1c and 1d exhibited potent hypochlolesterolemic activity, lowering the mice plasma triglyceride level up to 47% in Swiss albino mice after oral administration of 50 mg/kg/day for 8 days. Fenofibric acid ester prodrugs 1c–1h were found lipophilic like fenofibrate (1b), indicated by partition ...