PtCl2??Catalyzed Hydrative Cyclization of Trialkyne Functionalities to Form Bicyclic Spiro Ketones

HK Chang, S Datta, A Das, A Odedra…

Index: Chang, Hsu-Kai; Datta, Swarup; Das, Arindam; Odedra, Arjan; Liu, Rai-Shung Angewandte Chemie - International Edition, 2007 , vol. 46, # 25 p. 4744 - 4747

Full Text: HTML

Citation Number: 50

Abstract

The metal-catalyzed coupling of multifunctional groups [1–4] is synthetically useful because two or more carbon–carbon and carbon–heteroatom bonds can be formed simultaneously in a one-pot operation. Regiocontrolled hydrative cyclization of an alkyne with another functional group is particularly notable, as this procedure provides complex oxygenated carbocyclic molecules from readily available alkynes.[2–4] The reported examples are ...