Synlett

Synthesis of a biotin-labeled quorum-sensing molecule: Towards a general method for target identification

…, RL Nicholson, DM Marsden, JT Hodgkinson, X Su…

Index: Spandl, Richard J.; Nicholson, Rebecca L.; Marsden, David M.; Hodgkinson, James T.; Su, Xianbin; Thomas, Gemma L.; Salmond, George P. C.; Welch, Martin; Spring, David R. Synlett, 2008 , # 14 p. 2122 - 2126

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Citation Number: 3

Abstract

Abstract The synthesis of bacterial quorum-sensing regulator N-(3-oxohexanoyl)-l- homoserine lactone (OHHL) and biotin-tagged OHHL is reported. The latter will be applied to developing a general method to address the 'target identification problem'in chemical genetics.