Regioselective synthesis of 4-chloro-3-hydroxyanthranilic acid, a potent in vitro inhibitor of 3-hydroxyanthranilic acid oxygenase activity from rat brain

A Melikian, R Boigegrain, JP Kan, P Soubrie

Index: Melikian; Boigegrain; Kan; Soubrie European Journal of Medicinal Chemistry, 1990 , vol. 25, # 3 p. 267 - 270

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Citation Number: 4

Abstract

Abstract In the kynurenine metabolic pathways of tryptophan in kidney, liver and brain, 3- hydroxyanthranilic oxygenase (3-HAO, EC 1.13. 11.6) catalyses the conversion of 3- hydroxyanthranilic acid to quinolinic acid, an excitatory amino acid putatively involved in brain neurodegenerative disorders. The compound 4-chloro-3-hydroxyanthranilic acid is an irreversible inhibitor of 3-HAO in the liver and the kidney. We describe here a new, ...