Aryl sulfonamido tetralin inhibitors of the Kv1. 5 ion channel

MF Gross, NA Castle, A Zou, AD Wickenden…

Index: Gross, Michael F.; Castle, Neil A.; Zou, Anruo; Wickenden, Alan D.; Yu, Weifeng; Spear, Kerry L. Bioorganic and Medicinal Chemistry Letters, 2009 ,  vol. 19,  # 11  p. 3063 - 3066

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Citation Number: 8

Abstract

Aryl sulfonamido tetralins based on lead compound 2a were synthesized and evaluated for Kv1. 5 inhibitory activity. Several compounds having IC50 values less then 0.1 μM were identified. Kv1. 5 inhibitors have the potential to be atrium-selective agents for the treatment of atrial fibrillation.