Abstract A convenient synthesis of furo [3, 2-b] pyridine and its 2-and 3-methyl derivatives from ethyl 3-hydroxypiconate (1) is described. The hydroxy ester 1 was O-alkylated with ethyl bromoacetate or ethyl 2-bromopropionate to give the diester 2a or 2b. Cyclization of compound 2a afforded ethyl 3-hydroxyfuro [3, 2-b] pyridine-2-carboxylate (3) which in turn was hydrolyzed and decarboxylated to give furo [3, 2-b] pyridin-3-(2H)-one (4a). ...
![3-methylfuro[3,2-b]pyridine-2-carboxylic acid,ethyl ester Structure](https://image.chemsrc.com/caspic/180/107096-10-6.png)
![2-methyl-2,3-dihydrofuro[3,2-b]pyridin-3-ol Structure](https://image.chemsrc.com/caspic/235/107096-04-8.png)