Reductive thiolation approach to pure cyclobutyl phenyl sulfide

MCT Fyfe, CM Rasamison

Index: Fyfe, Matthew C. T.; Rasamison, Chrystelle M. Organic Preparations and Procedures International, 2005 , vol. 37, # 2 p. 194 - 197

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Citation Number: 5

Abstract

Cyclobutyl phenyl sulfide (1) is a precursor of cyclobutyl phenyl sulfoxide, a reagent extremely useful for the synthesis of spirocyclic cyc1opentanones. l” In our laboratories, we required a method for the large scale production of 1, a compound necessary for the construction of a range of potent glucokinase activators (GKAs)~ that could form the basis of a treatment for type 2 diabetes. Here, we discuss how the difficulties associated with ...