The purpose of this study was the synthesis and evaluation of the first members of a new series of unsymmetrical aryl glucosyl disulfides. Such cleavable molecules are potentially useful as solubilizing agents for membrane proteins. Unsymmetrical disulfides 6a-d were prepared as follows. The corresponding phenol was converted into the N, N- dimethylcarbamothioic acid ester (eg, 2a) which was rearranged thermally to the thioester ...
