Pharmaceutical Chemistry Journal

Synthesis of 5-(arylmethylene) hexahydropyrimidine-2, 4, 6-triones

SI Zav'yalov, AG Zavozin

Index: Zav'yalov, S. I.; Zavozin, A. G. Pharmaceutical Chemistry Journal, 1994 , vol. 28, # 11 p. 841 - 842 Khimiko-Farmatsevticheskii Zhurnal, 1994 , vol. 28, # 11 p. 49

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Abstract

5-(Arylmethylene) hexahydropyrimidine-2, 4, 6-triones (AP), which exhibit immunodepressive [1], fungicidal [2] and antiinflammatory activity [3], are synthesized by heating barbituric acid (I) with aromatic aldehydes [4-7]. We have demonstrated that this