Synthesis and intramolecular hydrogen bonding and biochemical studies of clitocine, a naturally occurring exocyclic amino nucleoside

RJ Moss, CR Petrie, RB Meyer Jr, LD Nord…

Index: Moss, Randall J.; Petrie, Charles R.; Meyer, Rich B.; Nord, L. Dee; Willis, Randall C.; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 786 - 790

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Citation Number: 56

Abstract

1 2 3 Robins et aL4 reported the first synthesis of the exocyclic amino nucleoside, 4-amino-8- (~-~-ribofuranosylamino) py-rimido [5, 4-d] pyrimidine (2), via a rearrangement of 6-cyano-9- PD-ribofuranosylpurine. Townsend and Robins6 reported the synthesis of 2-amino-6- hydroxy-5-(N-formyl-N-methylamino)-4-(~-ribofuranosylamino) pyrimi-dine by ring cleavage of 7-methylguanosine with aqueous ammonia. Niedballa and Vorbrugged isolated N4-( ...