Sulfur-containing 1, 3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors

…, S Barone, BJ Bradbury, U Kammula…

Index: Jacobson, Kenneth A.; Kiriasis, Leonidas; Barone, Suzanne; Bradbury, Barton J.; Kammula, Udai; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1873 - 1879

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Citation Number: 41

Abstract

Results Chemistry. Various 8-substituted xanthine and thioxanthine derivatives were synthesized via 1, 3-dialkyl-5, 6-diaminouracils as shown in Scheme I. The substituted uracil and 2-thiouracil intermediates were prepared via an optimized Traube synthe~ is.~?'~ 1, 3- Dimethyl-and 1, 3-di-n-propyl-5, 6-diaminouracil and their 2-thio derivatives were obtained by condensation of the corresponding dialkyl urea (4a and-b) or thiourea (4c and-d) with ...