Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-Chlorophenyl)-1, 4-diazepan-1-yl]-1-(4-fluorophenyl) butan-1-one

SY Ablordeppey, R Altundas, B Bricker, XY Zhu…

Index: Ablordeppey, Seth Y.; Altundas, Ramazan; Bricker, Barbara; Zhu, Xue Y.; Suresh Kumar, Eyunni V.K.; Jackson, Tanise; Khan, Abdul; Roth, Bryan L. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 15 p. 7291 - 7301

Full Text: HTML

Citation Number: 33

Abstract

The synthesis and exploration of novel butyrophenones have led to the identification of a diazepane analogue of haloperidol, 4-[4-(4-chlorophenyl)-1, 4-diazepan-1-yl]-1-(4- fluorophenyl) butan-1-one (compound 13) with an interesting multireceptor binding profile. Compound 13 was evaluated for its binding affinities at DA subtype receptors, 5HT subtype receptors, H-1, M-1 receptors and at NET, DAT, and SERT transporters. At each of these ...