Journal of medicinal chemistry

Spermexatin and spermexatol: New synthetic spermidine-based siderophore analogs

SK Sharma, MJ Miller, SM Payne

Index: Sharma, Sushil K.; Miller, Marvin J.; Payne, Shelley M. Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 357 - 367

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Citation Number: 81

Abstract

Syntheses of hexanediamine-based dihydroxamate (Hexamate), spermidine-based trihydroxamate (Spermexatins), and spermidine-based mixed siderophore analogues (Spermexatols) are described. Key intermediates include the N-hydroxysuccinimide esters of various hydroxamic acids, eg, malonohydroxamate, succinohydroxamate, and glutarohydroxamate. These intermediates were synthesized, characterized, and ...

~81%

~98%

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