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Synthesis of variously 9, 9-dialkylated octahydropyrimido [3, 4-a]-s-triazines with potential antifungal activity

A Ghaib, S Ménager, P Vérité, O Lafont

Index: Ghaib, Amar; Menager, Sabine; Verite, Philippe; Lafont, Olivier Farmaco, 2002 , vol. 57, # 2 p. 109 - 116

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Citation Number: 25

Abstract

9, 9-Dialkyloctahydropyrimido [3, 4-a]-s-triazines were synthesized by iminodimethylation reaction between a 5, 5-dialkyl-6-aminopyrimidine-2, 4 (3H, 5H)-dione, a substituted aniline and two moles of formaldehyde. The synthesis of 5, 5-dialkyl-6-aminopyrimidinedione consisted of the condensation of urea with ethyl 2, 2-dialkylcyanoacetates. 18 Octahydropyrimido [3, 4-a]-s-triazines were synthesized and compounds resulting from a ...