Physical Chemistry Chemical Physics 2011-12-07

Interactions of an asymmetric amine with a non-C2 symmetric Cu-salen complex: an EPR/ENDOR and HYSCORE investigation.

Ignacio Caretti, Emma Carter, Ian A Fallis, Damien M Murphy, Sabine Van Doorslaer

Index: Phys. Chem. Chem. Phys. 13(45) , 20427-34, (2011)

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Abstract

Single enantiomers of R-/S-methylbenzylamine (MBA) were found to selectively form adducts with the chiral non-C(2) symmetric Cu-salen complex N-(3,5-di-tert-butylsalicylidene)-N'-(salicylidene)-cyclohexane-1,2-diamine copper(II), hereafter labelled [Cu(3)]. The g/A spin Hamiltonian parameters of this Cu(II) complex showed a decrease in symmetry from axial to rhombic upon formation of the [Cu(3)] + MBA adducts. The selectivity in enantiomeric discrimination was found to be only 59 ± 5% in favour of the heterochiral R,R'-[Cu(3)] + S-MBA and S,S'-[Cu(3)] + R-MBA adducts. This was directly evidenced by W-band EPR spectroscopy. The observed low selectivity for enantiomer discrimination is primarily attributed to the loss of the bulky tert-butyl groups from the 3,5 positions of [Cu(3)] compared to the parent N,N'-bis(3,5-di-tert-butylsalicylidene)-cyclohexane-1,2-diamine copper(II) ligand (labelled [Cu(1)]). The structure of the [Cu(3)] complex in the presence and absence of coordinating amine was further investigated by analysis of the ligand hyperfine interactions, as revealed through Q-band CW-ENDOR, X-band Davies ENDOR and HYSCORE. (1)H couplings from the -NH(2) group of the amine, observed by ENDOR and HYSCORE, provided direct evidence of amine coordination.