Chemical Communications 2013-02-18

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation.

Qingzhi Zhang, Agnieszka Kulczynska, David J Webb, Ian L Megson, Nigel P Botting

Index: Chem. Commun. (Camb.) 49(14) , 1389-91, (2013)

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Abstract

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).