Journal of Chromatography B 2014-04-15

Characterization of in vitro metabolites of JWH-018, JWH-073 and their 4-methyl derivatives, markers of the abuse of these synthetic cannabinoids

Veniero Gambaro, Sebastiano Arnoldi, Stefania Bellucci, Eleonora Casagni, Lucia Dell’Acqua, Laura Fumagalli, Marco Pallavicini, Gabriella Roda, Chiara Rusconi, Ermanno Valoti

Index: J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 957 , 68-76, (2014)

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Abstract

• Optimization of a suitable extraction protocol for alkylindoles and their metabolites from biological fluids. • Detection of alkylindoles and their metabolites by means of the GC/MS method adopted by UNODC. • In vitro incubation with human liver microsomes of alkylindoles. • Study of the metabolism of 1-butyl-3-(1-(4-methyl)naphthoyl)indole for the first time.