A direct approach to the synthesis of famciclovir and penciclovir

…, M Dales, GP Johnson, S O'Donnell…

Index: Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994

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Citation Number: 18

Abstract

Abstract Reaction of 2-amino-6-chloropurine with triethyl 3-bromopropane-1, 1, 1- tricarboxylate followed by decarbethoxylation/transesterification of the unpurified product was the key sequence in synthesising both the anti-herpesvirus agent penciclovir and its oral from famciclovir in three isolated steps.