Organic & Biomolecular Chemistry 2013-02-07

New 2,3-diaminopropionic acid inhibitors of AGE and ALE formation.

Nicolas Audic, Guy Potier, N André Sasaki

Index: Org. Biomol. Chem. 11(5) , 773-80, (2013)

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Abstract

Novel 2,3-diaminopropionic acid-based molecules were synthesised and tested successfully as glyoxal/methylglyoxal scavengers and as AGE inhibitors. Addition of an 8-hydroxyquinoline moiety led to an increase of the overall activity. The compounds tested in this study were also proved to be efficient in trapping ALE precursor malondialdehyde.