Identification of the benzodiazepines as a new class of antileishmanial agent

…, GD Coxon, G Owusu-Dapaah, E McFarlane…

Index: Clark, Rachel L.; Carter, Katharine C.; Mullen, Alexander B.; Coxon, Geoffrey D.; Owusu-Dapaah, George; McFarlane, Emma; Duong Thi, M. Dao; Grant, M. Helen; Tettey, Justice N.A.; Mackay, Simon P. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 3 p. 624 - 627

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Citation Number: 40

Abstract

The continual increase in drug resistance; the lack of new chemotherapeutic agents; the toxicity of existing agents and the increasing morbidity with HIV co-infection mean the search for new antileishmanial agents has never been more urgent. We have identified the benzodiazepines as a structural class for antileishmanial hit optimisation, and demonstrated that their in vitro activity is comparable with the clinically used drug, sodium stibogluconate ...