Chemistry: A European Journal 2012-04-16

Palladium-catalyzed carbonylative Heck reaction of aryl bromides with vinyl ethers to 3-alkoxy alkenones and pyrazoles.

Johannes Schranck, Xiao-Feng Wu, Helfried Neumann, Matthias Beller

Index: Chemistry 18(16) , 4827-31, (2012)

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Abstract

Three COming together: The first carbonylative Heck coupling reaction of aryl bromides and vinyl ethers leading to 1-aryl-3-alkoxy-2-propen-1-ones has been established (see scheme). Based on this coupling methodology, a novel one-pot synthesis of aryl-substituted pyrazoles was also realized.Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.