European Journal of Drug Metabolism and Pharmacokinetics 2001-01-01

Autoradiography in brain of Macaca fascicularis monkeys after injection of acetyl-DL-leucine [2-14C] (Tanganil).

P Benard, H Cousse, T Bengone, C Germain

Index: Eur. J. Drug Metab. Pharmacokinet. 26(1-2) , 71-6, (2001)

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Abstract

Acetyl-DL-leucine [2-14C]: Tanganil a antivertigal drug has been injected intravenously in two macaca monkeys which have been sacrificed 2 and 5 minutes later. Radioactivity distribution has been studied by autoradiography in the brain. An important uptake of radioactivity is localized in the cortical structures and in several tisses such as nuclei of the vestibular system, including the inner ear.