Advanced Healthcare Materials 2012-07-01

Hybrid BaYbF(5) nanoparticles: novel binary contrast agent for high-resolution in vivo X-ray computed tomography angiography.

Yanlan Liu, Kelong Ai, Jianhua Liu, Qinghai Yuan, Yangyang He, Lehui Lu

Index: Adv. Healthc. Mater. 1(4) , 461-6, (2012)

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Abstract

A novel CT contrast agent denoted as BaYbF(5) @SiO(2) @PEG is presented. The as-prepared nanoparticles exhibit significantly enhanced contrast efficacy relative to clinical iodinated agents and maintain higher X-ray attenuation at different voltages, suitable for diagnostic imaging of various patients. Prolonged circulation time in vivo and low toxicity mean the nanoparticles perform excellently in in-vivo X-ray CT angiography.Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.