A mild, pyridine-borane-based reductive amination protocol

MD Bomann, IC Guch, M DiMare

Index: Bomann, Mark D.; Guch, Ian C.; DiMare, Marcello Journal of Organic Chemistry, 1995 , vol. 60, # 18 p. 5995 - 5996

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Citation Number: 161

Abstract

The in situ reductive amination of ketones or aldehydes has been an important part of the synthetic chemist's repertoire since the introduction of a procedure based on cyanoborohydride, l yet the toxicity and disposal problems associated with this material has led to a continuing search for alternative reductant^.^" We would like to report a simple and mild in situ reductive amination protocol using methanolic pyridine-borane and 4 A ...