Xenobiotica 1980-04-01

Whole-body distribution an Malpighian tubule transport of 2',5-dichloro-4'-nitrosalicylanilide (Bayer 73) and 3-trifluoromethyl-4-nitrophenol in larvae of the aquatic midge Chironomus tentans.

C R Hansen, J D Gauss, J A Kawatski

Index: Xenobiotica 10(4) , 257-63, (1980)

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Abstract

1. Residues of the lampricides 14C-Bayer 73 (2',5-dichloro-4'-nitrosalicylanilide) and 14C-TFM (3-trifluoromethyl-4-nitrophenol) were absorbed from aqueous sublethal concn. by aquatic larvae of the midge Chironomus tentans. 2. Toxicant residues were widely distributed during early hours of exposure, but later and during a 24-h post-exposure period, they became concentrated in the trunk and intestinal tract; the posterior movement of Bayer 73 was more rapid than that of TFM. 3. During 4-h tests, Malpighian tubules of the chironomid actively transported Bayer 73 and TFM in vitro, and on a per tubule basis, more TFM was transported than Bayer 73. 4. Potassium cyanide inhibited tubule transport; serotonin had no effect.