2-(4-Chlorobenzyl)-3-hydroxy-7, 8, 9, 10-tetrahydrobenzo [H] quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic …

N Kaila, K Janz, A Huang, A Moretto…

Index: Journal of Medicinal Chemistry, , vol. 50, # 1 p. 40 - 64

Full Text: HTML

Citation Number: 73

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. The target quinolines (2) were synthesized using the Pfitzinger reaction between an isatin (3) and an α-keto acetate (4), as described previously (Scheme 1). 25,31 The isatins ...

Continuous flow generation and reactions of anhydrous diazom...

[Mastronardi, Federica; Gutmann, Bernhard; Oliver Kappe Organic Letters, 2013 , vol. 15, # 21 p. 5590 - 5593]

Monohalomethyllithium XCH2Li: stabilization of a potential s...

[Tarhouni, R.; Kirschleger, B.; Rambaud, M.; Villieras, J. Tetrahedron Letters, 1984 , vol. 25, # 8 p. 835 - 838]

Non??Racemic Halohydrins via Biocatalytic Hydrogen??Transfer...

[Advanced Synthesis and Catalysis, , vol. 347, # 14 p. 1827 - 1834]

Alkylation of benzene with α-diazoketones via cycloheptatrie...

[McKervey, M. Anthony; Russell, D. Noel; Twohig, M. Fiona Journal of the Chemical Society, Chemical Communications, 1985 , # 8 p. 491 - 492]

The chemistry of small ring compounds. Part 30. Reactions of...

[Recueil des Travaux Chimiques des Pays-Bas, , vol. 94, p. 64 - 69]