Tetrahedron

A highly efficient Pd–C catalytic hydrogenation of pyridine nucleus under mild conditions

C Cheng, J Xu, R Zhu, L Xing, X Wang, Y Hu

Index: Cheng, Chuanjie; Xu, Jimin; Zhu, Rui; Xing, Lixin; Wang, Xinyan; Hu, Yuefei Tetrahedron, 2009 , vol. 65, # 41 p. 8538 - 8541

Full Text: HTML

Citation Number: 5

Abstract

A synergistic Pd–C catalytic hydrogenation of 4-pyridinecarboxamides straightforward to 4- piperidinecarboxamide hydrochlorides was developed in the presence of ClCH2CHCl2. It provided a novel strategy for highly efficient hydrogenation of pyridine nuclear by using low- cost Pd–C catalyst under mild conditions.