Bioorganic & Medicinal Chemistry Letters 2001-07-23

Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y(12)).

R M Scarborough, A M Laibelman, L A Clizbe, L J Fretto, P B Conley, E E Reynolds, D M Sedlock, H Jantzen

Index: Bioorg. Med. Chem. Lett. 11(14) , 1805-8, (2001)

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Abstract

Novel non-nucleoside tricyclic platelet ADP receptor (P2Y(12)) antagonists have been discovered that bind reversibly and with high affinity to the platelet receptor. Condensation of various 2-aminobenzothiazoles with chlorosulfonylacetyl chloride affords these novel tricyclic heterocycles, which are novel and unpredicted products of this reaction.