Journal of Labelled Compounds and Radiopharmaceuticals 2013-06-30

Syntheses of deuterium labeled prenyldiphosphate and prenylcysteine analogues for in vivo mass spectrometric quantification.

Thangaiah Subramanian, Karunai Leela Subramanian, Manjula Sunkara, Fredrick O Onono, Andrew J Morris, H Peter Spielmann

Index: J. Labelled Comp. Radiopharm. 56(8) , 370-5, (2013)

Full Text: HTML

Abstract

A Wittig reaction employing Li(CD3)2CP(C6H5)3 was used to prepare d6-farnesol and d6-geranylgeraniol. Reductive amination of aniline-2,3,4,5,6-d5 was used to prepare the unnatural isoprenoid analogues d5-anilinogeraniol and d5-anilinofarnesol. All of these deuterated isoprenols were elaborated into their diphosphate and cysteine thioether derivatives suitable for use as stable-isotope labeled standards for quantitative mass spectrometric analysis.Copyright © 2013 John Wiley & Sons, Ltd.