Tetrahedron

Highly efficient copper/palladium-catalyzed tandem Ullman reaction/arylation of azoles via C–H activation: synthesis of benzofuranyl and indolyl azoles from 2-(gem- …

W Chen, M Wang, P Li, L Wang

Index: Chen, Wei; Wang, Min; Li, Pinhua; Wang, Lei Tetrahedron, 2011 , vol. 67, # 33 p. 5913 - 5919

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Citation Number: 19

Abstract

In this paper, a novel and highly efficient copper/palladium-catalyzed tandem intramolecular Ullman-type C–O (N) coupling reaction of 2-(gem-dibromovinyl) phenols (anilines) followed by an intermolecular arylation of azoles through C–H activation has been developed. In the presence of CuBr with Pd (PPh3) 2Cl2 used as co-catalyst, and LiOtBu as a base, the one- pot reactions of 2-(gem-dibromovinyl) phenols and 2-(gem-dibromovinyl) anilines with a ...