Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 1998-07-01

[An experimental study on effects of antimony on anti-oxidase system on liver mitochondria in mice].

A Wang, F An, Z Gao

Index: Zhonghua Yu Fang Yi Xue Za Zhi 32(4) , 229-30, (1998)

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Abstract

To explore the mechanisms of toxic liver damage caused by antimony.Experimental mice were injected peritoneally 40 mg/kg of antimony trioxide daily for 28 days to observe the effects of it on the anti-oxidase system in their liver mitochondria.Activities of aspartate aminotransferase and alanine aminotransferase increased obviously in the experimental animals, and those of superoxide dismutase and glutathione peroxidase in liver mitochondria lowered, as compared to those in the control animals with statistical significance. Content of malonyl dialdehyde in the liver mitochondria was 47.27 +/- 1.21 mumol/L in the experimental animals, significantly higher than that in controls.It suggested that the mechanism of liver damage caused by antimony associated with injury to the ability of anti-oxidation and lipid peroxidation in the liver mitochondria.