Transplantation Proceedings 2012-11-01

Relation of Urinary Gene Expression of Epithelial-Mesenchymal Transition Markers With Initial Events and 1-Year Kidney Graft Function

C. Gomez-Alamillo, M.A. Ramos-Barron, A. Benito-Hernandez, E. Rodrigo, J.C. Ruiz, C. Agüeros, M. Sanchez, M. Arias

Index: Transplant. Proc. 44(9) , 2573-6, (2012)

Full Text: HTML

Abstract

Introduction Renal dysfunction due to acute rejection (AR), acute tubular necrosis, or calcineurin inhibitors toxicity is related to development of interstitial fibrosis/tubular atrophy (IF/TA) and graft survival. Determination of serum creatinine (sCr) displays poor sensitivity as a marker for early detection of graft dysfunction. Kidney biopsy is an accurate but invasive procedure for the diagnosis. The levels of urinary mRNA of genes that regulate epithelial-mesenchymal transition (EMT) can reflect early damage and detect the development of IF/TA. Repeated studies of these genes can provide noninvasive information about the evolution of the graft, facilitating early diagnosis and treatment.