Archives of Pharmacal Research 2001-02-01

Photocleavage of DNA by 4'-bromoacetophenone analogs.

R Jeon, P A Wender

Index: Arch. Pharm. Res. 24(1) , 39-43, (2001)

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Abstract

4'-Bromoacetophenone analogs, which are able to generate monophenyl radicals capable of hydrogen atom abstraction, were investigated as possible photoinducible DNA cleaving agents. The potential of 4'-bromoacetophenone as a possible new DNA cleaver is explored. Pyrrolecarboxatmid conjugated 4'-bromoacetophenones, in particular, DNA cleaving activity and sequence-selectivity on the contiguous AT base pair sites.