Tetrahedron Letters

Simple synthesis of fresh alkyl iodides using alcohols and hydriodic acid

SM Klein, C Zhang, YL Jiang

Index: Klein, Suzane M.; Zhang, Cungen; Jiang, Yu Lin Tetrahedron Letters, 2008 , vol. 49, # 16 p. 2638 - 2641

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Citation Number: 18

Abstract

A simple synthesis of fresh alkyl iodides using alcohols and hydriodic acid (HI) is reported. The alkyl iodides were obtained in quick and easy work-up with good to excellent yields (66– 94%) and very high purities (97–99%). Freshly prepared iodomethane and 1-iodobutane were applied to synthesize biologically relevant 3, 7-dimethyladenine and 9-butyladenine, which were characterized thoroughly using 1D and 2D NMR, individually.