Bioorganic & Medicinal Chemistry Letters 2006-04-01

Inhibition of intercellular junctional communication in human fibroblasts by triphenylmethane, triphenylmethylchloride, tetraphenylboron and related compounds.

Maura Lodovici, Stefano Menichetti, Caterina Viglianisi, Silvia Caldini, Elisa Giuliani

Index: Biochim. Biophys. Acta 847(1) , 1-7, (1985)

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Abstract

Hydroxylated 4-thiaflavans, possessing the antioxidant features of catechol containing flavonoids and/or tocopherols, were evaluated as protective agents against oxidation damage induced in herring sperm DNA by cumene hydroperoxide (CumOOH) or by the glutathione/ferric ion (GSH/Fe(3+)) system. Our data indicate that the effective protection exerted by some of the tested compounds is overall higher than those provided by catechin and alpha-tocopherol, which might be attributed both to the scavenging properties and chelation of Fe(2+) ions.