Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1986-01-01

Ames Salmonella/mammalian-microsome testing of peptides and peptide synthesis reagents.

J S Allen, J Panfili

Index: Mutat. Res. 170(1-2) , 23-9, (1986)

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Abstract

The Ames Salmonella/mammalian-microsome assay was used to evaluate the bacterial mutagenicity of 6 bioactive peptides and of 11 chemical reagents used in peptide synthesis. Samples of 2 reagents, bis(2-oxo-3-oxazolidinyl)phosphinic chloride and fluoren-9-ylmethyl chloroformate, showed mutagenic activity with strains TA100 and TA1535, and with TA1537, respectively. No mutagenic activity was found with the bioactive peptides or with the other 9 peptide synthesis reagents.