Epilepsy Research 2014-11-01

A potential effect of ganaxolone in an animal model of infantile spasms

Mi-Sun Yum, Minyoung Lee, Tae-Sung Ko, Libor Velíšek

Index: Epilepsy Res. 108(9) , 1492-500, (2014)

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Abstract

• Ganaxolone pretreatment dose-dependently suppressed NMDA induced spasms in rats. • Randomized ganaxolone trial in rats with spasms was effective. • Ganaxolone treatment ameliorated the behavioral change after multiple NMDA spasms. • Ganaxolone can be a potential novel therapy to treat infantile spasms.