Sterics versus Electronics: Regioselective Cross??Coupling of Polybrominated Thiophenes

CM Amb, SC Rasmussen

Index: Amb, Chad M.; Rasmussen, Seth C. European Journal of Organic Chemistry, 2008 , # 5 p. 801 - 804

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Citation Number: 16

Abstract

Abstract Methods for the regioselective cross-coupling of 2, 3, 5-tribromothiophene have been developed in which selective aryl–aryl coupling occurs at the 5-position with yields up to 63%. The difference in reactivity of the α-and β-positions then allows sequential regioselective couplings first at the 2-position, followed by the 3-position. Such regioselective cross-coupling allows unprecedented control in the generation of ...