Organic Letters 2013-12-20

Rhodium-catalyzed direct addition of aryl C-H bonds to nitrosobenzenes at room temperature.

Bing Zhou, Juanjuan Du, Yaxi Yang, Huijin Feng, Yuanchao Li

Index: Org. Lett. 15(24) , 6302-5, (2013)

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Abstract

An unprecedented Rh-catalyzed direct addition of aryl C-H bonds to nitrosobenzenes has been developed under very mild reaction conditions (room temperature). The reaction is highly step-, atom-, and redox-economic and compatible with air and water to N-selectively provide a variety of N-diarylhydroxylamines in good to excellent yields. More importantly, this process may provide a new direction for C-N bond formation through direct C(sp(2))-H functionalization.