Bioscience, Biotechnology, and Biochemistry 2010-01-01

Concise synthesis of Valerena-4,7(11)-diene, a highly active sedative, from valerenic acid.

Takashi Kitayama, Genki Kawabata, Michiho Ito

Index: Biosci. Biotechnol. Biochem. 74(9) , 1963-4, (2010)

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Abstract

A concise synthesis of valerena-4,7(11)-diene with potent sedative activity was achieved in three steps involving, reduction of carboxylic acid, bromination of the resulting alcohol, and reduction of the bromide from valerenic acid in a 63% total yield. This synthetic method makes it possible to provide further materials for biological testing to realize comprehensive SAR studies.