Bioorganic & Medicinal Chemistry Letters 2013-04-01

A new dehydroabietic acid-based arylamine fluorescent probe: Synthesis, structure analysis and in vitro biodiagnose function.

Hong Gao, Shanshan Chen, Xiaoping Rao, Shibin Shang, Zhanqian Song

Index: Bioorg. Med. Chem. Lett. 23(7) , 2254-9, (2013)

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Abstract

A new fluorescent probe (methyl 13-(α-naphthalene)aminodeisopropyldehydroabietate) has been synthesized, and its structure was optimized by theoretical DFT calculation and determinated by single-crystal X-ray diffraction analysis. The optimized data are in agreement with the experimental values. The fluorescence properties, photostability, cell toxicity and in vitro fluorescence imaging of the compound have been investigated. The results indicated that it can be effectively taken up by HeLa, 7721, 7901 and A549 cells and strong blue fluorescence signals were detected in these cells.Copyright © 2013 Elsevier Ltd. All rights reserved.