Eksperimental'naia i klinicheskaia farmakologiia 2011-01-01

[Effect of migrepin on activity of trigeminal nucleus caudalis neurons].

A Iu Sokolov, O A Liubashina, Iu D Ignatov, S S Panteleev, A O Syrovaia, T V Zviagintseva

Index: Eksp. Klin. Farmakol. 74(5) , 13-6, (2011)

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Abstract

Neurophysiological experiments on anesthetized rats were used to study the effects of various doses (12.5, 25, 37.5 mg/kg, i.v.) of drug composition migrepin (representing a combination of potassium-2,4-dichlorobenzoate, carbamazepine, and caffeine) on background firing of the trigeminal nucleus caudalis neurons and their responses to electrical stimulation of the dura mater. It was found that migrepin produces direct, dose-dependent inhibitory action on functional activity of TNC neurons. The results confirmed anti-migraine properties of the drug but did not exclude the necessity to study its action in clinical trials.