Antimicrobial Agents and Chemotherapy 2010-05-01

Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay.

Gengrong Lin, Lois M Ednie, Peter C Appelbaum

Index: Antimicrob. Agents Chemother. 54(5) , 2258-61, (2010)

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Abstract

Synergy time-kill studies of 47 methicillin-resistant Staphylococcus aureus strains with differing resistance phenotypes showed that combinations of subinhibitory concentrations of ACHN-490 and daptomycin yielded synergy against 43/47 strains at 24 h, while the combination was indifferent against the remaining 4 strains. ACHN-490 and ceftobiprole showed synergy in 17/47 strains tested at 24 h, while 6/47 strains showed synergy for subinhibitory combinations of ACHN-490 and linezolid.