Catalytic direct arylation with aryl chlorides, bromides, and iodides: intramolecular studies leading to new intermolecular reactions

LC Campeau, M Parisien, A Jean…

Index: Campeau, Louis-Charles; Parisien, Mathieu; Leblanc, Melissa; Fagnou, Keith Journal of the American Chemical Society, 2004 , vol. 126, # 30 p. 9186 - 9187

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Citation Number: 506

Abstract

A catalyst for the intramolecular direct arylation of a broad range of simple and heterocyclic arenes with aryl iodides, bromides, and chlorides has been developed. These reactions occur in excellent yield and are highly selective. Studies with aryl iodides substrates revealed that catalyst poisoning occurs due to the accumulation of iodide in the reaction media. This can be overcome by the addition of silver salts which also permits these ...