Carbohydrate Research 2006-07-24

A convenient gram-scale synthesis of uridine diphospho(13C6)glucose.

Zoran Dinev, Ahmad Z Wardak, Robert T C Brownlee, Spencer J Williams

Index: Carbohydr. Res. 341 , 1743-1747, (2006)

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Abstract

A simple gram-scale synthesis of uridine diphospho(13C6)glucose is presented from D-(13C6)glucose. The critical step uses a 1H-tetrazole-catalyzed coupling of 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl-1-phosphate and UMP-morpholidate. The uridine diphospho(13C6)glucose was used in the structural identification of (1-->3)-beta-D-glucan from Lolium multiflorum.