Organic Letters 2007-05-10

Catalytic asymmetric formation of beta-sultams.

Marian Zajac, René Peters

Index: Org. Lett. 9 , 2007, (2007)

Full Text: HTML

Abstract

beta-Sultams, highly strained sulfonyl analogues of beta-lactams, were prepared enantio- and diastereoselectively by tertiary amine catalyzed [2 + 2] cycloaddition reactions. The title compounds are practical precursors of highly enantioenriched biologically interesting beta-aminosulfonyl derivatives.