Synlett

AgI-PEG400-KI catalyzed environmentally benign synthesis of aroyl cyanides using potassium hexacyanoferrate (II) as the cyanating agent

Z Li, S Shi, J Yang

Index: Li, Zheng; Shi, Shengyi; Yang, Jingya Synlett, 2006 , # 15 p. 2495 - 2497

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Citation Number: 23

Abstract

Abstract A practical cyanation of aroyl chlorides with 0.2 equivalent of non-toxic cyanide source, K 4 [Fe (CN) 6], 3 mol% AgI, 4 mol% PEG-400, and 3 mol% KI as the catalyst system is described. The reactions were performed in DMF at room temperature and provided the corresponding aroyl cyanides in 64-89% yield, typically in less than ten hours.